Rett syndrome

Rett syndrome is an X-linked dominant disorder affecting girls almost exclusively (it is lethal to the male fetus). It occurs in 1 or 2 girls per 20,000. These girls develop normally until approximately 1 year of age, when language and motor development start to regress. The head circumference begins to fall off the curve at this time as well. These girls develop characteristic midline hand-wringing and unusual sighing. Autistic behaviors are typical. Unfortunately, no specific cause is known and no treatment has been sucessful.

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